USAID

Immediate fatalities: Epidemiological tracking and models (including analyses cited by public health researchers from Boston University and Harvard estimate that the initial aid freezes and contract terminations have already caused upwards of 300,000 to 600,000 excess deaths, two-thirds of which are young children.
Treatment collapse: Over 83% of USAID contracts were canceled, shutting down more than 1,700 clinical and treatment sites globally, causing stock-outs of antiretroviral drugs for HIV/AIDS, and halting critical tuberculosis and malaria interventions.
Disease surveillance: The termination of a 50-country disease surveillance network slowed outbreak response times from under 48 hours to more than two weeks.

WASH and sanitation failures: Halting water and sanitation funding (cut by roughly 86%) led to empty water towers and raw water consumption in vulnerable zones, triggering severe outbreaks like a major cholera surge in the Democratic Republic of Congo.
Complete withdrawal from crisis zones: The U.S. completely pulled out of operations in Mozambique and Afghanistan, and nearly left the DRC, leaving massive humanitarian vacuums where the U.S. previously supplied the majority of life-saving provisions.
Protection services lost: Safe spaces, psychosocial backing, and support systems for survivors of sexual violence and displaced women and girls were abruptly defunded in conflict zones like Yemen, Haiti, and Myanmar.

Research published in The Lancet projects that maintaining these funding cuts through 2030 could result in over 14 million excess all-age deaths—including more than 4.5 million deaths in children under five—alongside millions of new HIV and tuberculosis infections.